The general pooled analysis revealed a statistically significant percent decrease in body weight of the retatrutide team when compared to the sugar pill team after 36 weeks of therapy, with a total MD of − 14.33 (95% CI: − 18.27 to − 10.39, P retatrutide side Effects Heart</a> in overweight people with or without diabetes mellitus. Early trials of retatrutide disclosed that users can lose approximately a quarter of their body weight in under a year, making it almost two times as reliable as Ozempic.